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Journal of Hand Surgery (British and European Volume)
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Experimental Studies of the Effect of Bupivacaine on Peripheral Nerves

R. H. HELM
Y. S. LEE
R. W. H. PHO

From the Ministry of Health Experimental Surgery and the Hand Surgery Unit, National University of Singapore

0.5% Bupivacaine was administered around the sciatic nerve of rabbits by means of a catheter, over a period of ten days. Twenty nerves showed no histological changes, but in three there were areas of demyelination and axonal degeneration, especially near the surface of the nerve. However, similar changes occurred in two out of six nerves to which normal saline was administered instead, and it is suggested that the damage may have been caused by mechanical trauma from movement of the catheter.

Journal of Hand Surgery (British and European Volume), Vol. 12, No. 1, 19-22 (1987)
DOI: 10.1016/0266-7681(87)90046-5
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