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Journal of Hand Surgery (British and European Volume)
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Articles

Teratogenic Relationship between Polydactyly, Syndactyly and Cleft Hand

T. OGINO

From the Department of Orthopaedic Surgery, School of Medicine, Hokkaido University, Japan

Correspondence: T. Ogino, M.D., Dept. of Orthopaedic Surgery, School of Medicine, Hokkaido University, Kita-15, Nishi-7, Kitaku Sapporo, Japan.

Several investigators have suggested that polydactyly, syndactyly and cleft hand might have arisen from a common teratogenic mechanism. To confirm this hypothesis, 75 hands with these anomalies were analysed. Advanced cases with central polydactyly or osseous syndactyly in which the fusion area extends as far as the proximal phalanx and metacarpus are identical to typical cleft hand. The author has induced the same deformities using myleran in rat foetuses. The clinical features of these anomalies in rats were the same as those in clinical cases and the critical periods of these anomalies were also the same. The findings suggest that these hand anomalies may appear in human beings when the same teratogenic factor acts on the embryo at the same developmental period and that they should belong to the same teratogenic entity.

Journal of Hand Surgery (British and European Volume), Vol. 15, No. 2, 201-209 (1990)
DOI: 10.1016/0266-7681(90)90125-N
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P. R. Manske and K. C. Oberg
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