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Journal of Hand Surgery (British and European Volume)
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Articles

A New Fibrin Seal in Primary Repair of Peripheral Nerves

B. POVLSEN

From the Department of Plastic Surgery, Hand Surgery and Burns, University Hospital of linköping, and the Department of Cell Biology, University of Linköping, Sweden

Correspondence: Bo Povlsen, Department of Hand and Plastic Surgery, University Hospital of Linköping, University of Linköping, 581 85 Linköpíng, Sweden.

Fibrin sealing, with or without sutures, has become a commonly used technique in human nerve grafting with clinically good results, but is seldom used in primary repair of peripheral nerves. A prospective study was designed to evaluate the incidence of dehiscence in the traditional (Tisseel Kit) and a new "ready-to-use" fibrin seal preparation (Tisseel Duo), and the outcome following fibrin sealing was compared with microsurgical repair of peripheral nerves in rats. No dehiscence was seen in the Tisseel Duo group compared with 20% in the Tisseel Kit group. The electron micrographic evaluation following regeneration showed no significant difference from the microsuture group. Tisseel Duo should therefore be used instead of the traditional fibrin seal preparation when no sutures are used, and may prove to be an alternative to microsuture of peripheral nerves.

Journal of Hand Surgery (British and European Volume), Vol. 19, No. 1, 43-47 (1994)
DOI: 10.1016/0266-7681(94)90048-5
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