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Journal of Hand Surgery (British and European Volume)
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Articles

Nerve Growth Factor Enhances Nerve Regeneration through Fibronectin Grafts

I. H. WHITWORTH
R. A. BROWN
C. J. DORÉ
P. ANAND
C. J. GREEN
G. TERENGHI

From the Blond McIndoe Centre, Queen Victoria Hospital, East Grinstead; the Department of Plastic Surgery, The Rayne Institute, University College, London, Northwick Park Institute for Medical Research, Northwick Park Hospital, Harrow, Middlesex and the Department of Neurology, The Royal London Hospital, Whitechapel, London, UK

Correspondence: Dr G. Terenghi, Blond McIndoe Centre, Queen Victoria Hospital, Holtye Road, East Grinstead, Sussex RH19 3DZ, UK.

Soluble fibronectin and nerve growth factor (NGF) promote axonal regeneration when placed in silicone tubes. We investigated the ability of orientated fibronectin mats to bind and release bioactive NGF and the possibility of augmenting axonal regeneration following axotomy by using fibronectin conduits impregnated with NGF. The release of NGF was quantified using a fluorometric ELISA and bioactivity confirmed with a neuronal culture bioassay. Immunohistochemical techniques and computerized image analysis were used to assess the rate and volume of axonal and Schwann cell regeneration. The delivery of NGF to the site of injury produced an increase in the rate (P≤0.007) and volume (P≤0.004) of both axonal and Schwann cell regeneration when compared to conduits of plain fibronectin. We conclude that the local delivery of NGF by impregnated fibronectin conduits enhances axonal regeneration.

Journal of Hand Surgery (British and European Volume), Vol. 21, No. 4, 514-522 (1996)
DOI: 10.1016/S0266-7681(96)80058-1
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