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Journal of Hand Surgery (British and European Volume)
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Articles

Carpal Tunnel Syndrome in Amyotrophic Lateral Sclerosis and Late Onset Cerebellar Ataxia

M. MONDELLI
P. DELLA PORTA
A. ZALAFFI
A. ROSSI

From the Institute of Neurological Sciences, University of Siena, Italy

Correspondence: Dr M. Mondelli, Istituto di Scienze Neurologiche, Università di Siena, Viale Bracci, 53100 Siena, Italy.

We report on clinical and electrophysiological findings and management in nine patients who developed carpal tunnel syndrome during the course of amyotrophic lateral sclerosis and late onset cerebellar ataxia, two neurodegenerative diseases. The patients were treated with surgical decompression (five cases) and local steroid injections (four cases). Only one showed lasting relief of symptoms and significantly improved distal conduction in the median nerve at follow-up after 2 to 3 months. The symptoms and conduction data remained unchanged in three patients who could be followed for more than 1 year. We think that axonal neuropathy plays an important role in the development of carpal tunnel syndrome in these patients and accounts for the failure of the standard treatments.

Journal of Hand Surgery (British and European Volume), Vol. 21, No. 4, 553-558 (1996)
DOI: 10.1016/S0266-7681(96)80065-9
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