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Journal of Hand Surgery (British and European Volume)
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Articles

Nerve Xenograft Transplantation

Immunosuppression with FK-506 and RS-61443

D. HEBEBRAND
G. ZOHMAN
N. F. JONES

From the UCLA Hand Center, Los Angeles, USA

Correspondence: N. F. Jones MD, UCLA Hand Center, 200 UCLA Medical Plaza #140, Los Angeles, CA 90095, USA.

An experimental model has been developed to study the potential transplantation of nerve xenografts using the newer immunosuppressive agents RS-61443 and FK-506. Sciatic nerve grafts of 2 cm were transplanted from donor Golden Syrian hamsters into a 0.5 cm gap in the sciatic nerve of recipient Lewis rats. Walking track analysis, somatosensory evoked potentials and histology demonstrated improved regeneration across the nerve xenografts that had been immunosuppressed with RS-61443 and FK-506 compared with non-immunosuppressed controls, but the function never approached that seen in control isografts. Regeneration across nerve xenografts immunosuppressed with FK-506 was better than xenografts immunosuppressed with RS-61443.

Journal of Hand Surgery (British and European Volume), Vol. 22, No. 3, 304-307 (1997)
DOI: 10.1016/S0266-7681(97)80391-9
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