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Adhesion Receptors and Cytokine Profiles in Controlled Tourniquet Ischaemia in the Upper Extremity

From the Departments of Plastic, Hand and Burn Surgery, BG-Trauma Centre, Ludwigshafen and BG-University Hospital "Bergsmannsheil", Bochum, Germany

Correspondence: Prof. Dr G. Germann, Department of Plastic and Hand Surgery, Burn Centre, BG-Trauma Centre, Ludwig Guttmann Str. 13, 67071 Ludwigshafen, Germany.

Adhesion mechanisms mediated by cytokines have been recognized to play a crucial role in ischaemia–reperfusion mechanisms. Although this phenomenon has been well investigated in organ transplantation, little data is available from upper extremity surgery. Profiles of adhesion molecules (CD11/CD18), key cytokines (TNF- and IL-1), CD4+ and CD8+ lymphocytes, and polymorphonuclear neutrophils were investigated following controlled tourniquet ischaemia of the upper extremity for elective hand surgery. Data suggest that relatively short periods of ischaemia activate a mediator cascade and cell–cell interactions that may be associated with adverse pathopyhsiological effects on peripheral tissues after prolonged ischaemia.

Journal of Hand Surgery (British and European Volume), Vol. 22, No. 6, 778-782 (1997)
DOI: 10.1016/S0266-7681(97)80447-0


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