Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Sign In to gain access to subscriptions and/or personal tools.
Journal of Hand Surgery (British and European Volume)
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by FANSA, H.
Right arrow Articles by SCHNEIDER, W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by FANSA, H.
Right arrow Articles by SCHNEIDER, W.
Right arrowPubmed/NCBI databases
*Compound via MeSH
*Substance via MeSH
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Articles

The Effect of the Immunosuppressant FK 506 on Peripheral Nerve Regeneration Following Nerve Grafting

H. FANSA
G. KEILHOFF
S. ALTMANN
K. PLOGMEIER
G. WOLF
W. SCHNEIDER

From the Department of Plastic, Reconstructive and Hand Surgery, and the Institute of Medical Neurobiology, University of Magdeburg, Magdeburg, Germany

Correspondence: H. Fansa MD, Klinik für Plastische. Wiederherstellungs und Handchirurgie. Universitätsklinikum, Leipzigerstr. 44. 39120 Magdeburg, Germany. E-mail: hisham.fansa{at}medizin.uni-magdeburg.de

Nerve allografts are highly antigenic and require the continuous use of immunosuppressive drugs. Neurotoxic complications from immunosuppressant therapy with FK 506 have been noted in the central and peripheral nervous system although an increased rate of axonal regeneration has also been noted. Regeneration of peripheral nerve grafts was assessed in a rat model clinically and morphometrically after treatment for 2 and 6 weeks with two different doses of FK 506. Good regeneration was noted in all groups at 6 weeks. A significantly higher axon count was observed in both the FK 506 groups after 2 weeks regeneration compared with controls. This beneficial effect was not evident after 6 weeks of regeneration. Whether this is related to a pruning mechanism or to a down-regulation of regenerative processes in the nerve due to possible neurotoxic effects of FK 506 remains unknown.

Journal of Hand Surgery (British and European Volume), Vol. 24, No. 1, 38-42 (1999)
DOI: 10.1016/S0266-7681(99)90021-9
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?