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Journal of Hand Surgery (British and European Volume)
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Hyaluronic Acid Modulates Cell Proliferation Unequally in Intrasynovial and Extrasynovial Rabbit Tendons In Vitro

M. WIIG
S.-O. ABRAHAMSSON

From the Department of Hand Surgery, Uppsala University Hospital, Uppsala and Malmö University Hospital, Malmö, Sweden

Correspondence: M. Wiig MD PhD, Department of Hand Surgery, Uppsala University Hospital, S-751 85 Uppsala, Sweden. E-mail: monica.wiig{at}hand.uas.lul.se

As tendons differ in biochemical composition and cellular capacities, we have compared dose response effects of hyaluronic acid on cell proliferation and synthesis of matrix components in intermediate and proximal segments of intrasynovial deep flexor tendons and extrasynovial peroneus rabbit tendons in vitro. Compared with matched control tendons, hyaluronic acid inhibited cell proliferation in intermediate and proximal intrasynovial flexor tendon segments at the concentrations of 0.1–2.0 mg/ml and 0.5–2.0 mg/ml respectively, but in extrasynovial tendon segments only at the concentration of 0.5 mg/ml. Hyaluronic acid did not affect synthesis of proteoglycan, collagen and non-collagen protein in either type of tendon. These results show that hyaluronic acid modulates cell proliferation unequally in intra- and extrasynovial tendons without affecting the synthesis of matrix components in the two types of tendons, indicating differential hyaluronic acid sensitivity and a possible mechanism of action.

Journal of Hand Surgery (British and European Volume), Vol. 25, No. 2, 183-187 (2000)
DOI: 10.1054/jhsb.1999.0354
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