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Journal of Hand Surgery (British and European Volume)
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*FLUOROURACIL
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Articles

Early Breaking Strength of Repaired Flexor Tendon Treated with 5-Fluorouracil

S. CEROVAC
A. AFOKE
A. AKALI
D. A. McGROUTHER

From the Department of Plastic and Reconstructive Surgery, University College London, London, UK and the Department of Technology and Design, University of Westminster, London, UK

Correspondence: Miss Sonja Cerovac, 19 St Olave’s Close, Staines, Middlesex TW18 2LH E-mail: scerovac{at}aol.com

This study investigated the effect of a single intraoperative application of 5-fluorouracil, which may diminish peritendinous adhesion formation, on the tensile strength of repaired digital flexor tendons after 7, 14 and 21 days of healing. Twenty-seven deep flexor tendons from 14 rabbits were exposed to 5-fluorouracil (50 mg/ml) for 5 minutes immediately after repair whereas matched control tendons were exposed to normal saline. Tensile testing at 7, 14 and 21 days revealed no significant differences in the gap or ultimate strengths of the 5-fluorouracil treated and control tendons.

Journal of Hand Surgery (British and European Volume), Vol. 26, No. 3, 220-223 (2001)
DOI: 10.1054/jhsb.2000.0537
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