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Genetic Susceptibility in Dupuytren’s Disease: Lack of Association of a Novel Transforming Growth Factor β₂ Polymorphism in Dupuytren’s Disease

From the Hand Surgery Units, Wrightington Hospital, Wigan & Withington Hospital, Manchester and the ARC-Epidemiology Unit in collaboration with the Division of Cells, Immunology and Development, School of Biological Sciences, University of Manchester, Manchester, UK

Correspondence: Mr A Bayat, MRC Clinical Research Fellow, Dept ARC, University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, UK. E-mail: ardeshir.bayat{at}man.ac.uk

The genes involved in the pathogenesis of Dupuytren’s disease have yet to be identified. In this study, we tested for an association between Dupuytren’s disease (DD) and a novel insertion polymorphism within the 5'-untranslated region (5'-UTR), of the TGFβ₂ gene. DNA samples from 179 DD patients and 187 ethnically matched controls were examined. There was no statistically significant difference in TGFβ₂ allele frequency distributions between cases and controls for the TGFβ₂ polymorphism.

Journal of Hand Surgery (British and European Volume), Vol. 27, No. 1, 47-49 (2002)
DOI: 10.1054/JHSB.2001.0689


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