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Journal of Hand Surgery (British and European Volume)
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The Effect of Steroids on Dupuytren’s Disease: Role of Programmed Cell Death

R. M. D MEEK
S. McLELLAN
J REILLY
J. F. CROSSAN

From the University Department of Orthopaedics, Western Infirmary, Glasgow, Scotland, UK

Correspondence: Correspondence to: Mr R. M. D. Meek, University Department of Orthopaedic Surgery, Western Infirmary, Glasgow G12 6NT, UK. E-mail: rmdmeek{at}doctors.org.uk

This study compared the rates of proliferation and apoptosis of cells within nodules of Dupuytren’s disease and nodules from patients that had been injected preoperatively with steroid (Depo-Medrone). It also compared the effects of steroids in apoptosis in cultured Dupuytren’s cells and control fibroblasts from palmar fascia and fascia lata. Steroids reduced the rate of fibroblast proliferation and increased the rate of apoptosis of both fibroblasts and inflammatory cells in Dupuytren’s tissue. Steroids also produced apoptosis of cultured Dupuytren’s cells but not of palmar fascia and fascia lata cells.

Journal of Hand Surgery (British and European Volume), Vol. 27, No. 3, 270-273 (2002)
DOI: 10.1054/jhsb.2001.0742
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