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Journal of Hand Surgery (British and European Volume)
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Articles

A Prospective Randomised Clinical Trial of the Intra-Operative Use of 5-Fluorouracil on the Outcome of Dupuytren’s Disease

N. W. BULSTRODE
M. BISSON
B. JEMEC
A. L. PRATT
D. A. MCGROUTHER
A. O. GROBBELAAR

From the RAFT Institute of Plastic Surgery*, Mount Vernon Hospital, Northwood, MiddlesexHA6 2RN, UK, Wythenshaw Hospital, Southmoore Road, Manchester, UK

Correspondence: Mr A.O. Grobbelaar, Department of Plastic Surgery, Mount Vernon Hospital, Rickmansworth Road, Northwood, Middlesex HA6 2RN, UK., Tel.:+44-1923-844412; Fax: +44-20-74867288; E-mail: aog{at}talk21.com

5-Fluorouracil reduces proliferation rates of fibroblasts, myofibroblast differentiation and contractility of ocular fibroblasts in vitro. This double-blind randomized clinical trial assesses whether intra-operative topical treatment with 5-fluorouracil reduces the recurrence rate after limited excision of Dupuytren’s tissue. Patients with two-digit disease were randomized to having 5-fluorouracil (25 mg/ml) treatment for 5 minutes on one digit and placebo on the other.

Fifteen patients were enrolled with 18 months follow-up. There were no peri-operative complications. Wound healing was not delayed and there was no deterioration in the flexion deformity of the 5-fluorouracil treated digits. Patients were subsequently assessed by joint angle measurement at 3, 6, 12 and 18 months. There was no significant difference between control and 5-fluorouracil treated digits.

Key Words: Dupuytren’s • 5-fluorouracil • intra-operative use

Journal of Hand Surgery (British and European Volume), Vol. 29, No. 1, 18-21 (2004)
DOI: 10.1016/j.jhsb.2003.08.002
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