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Journal of Hand Surgery (British and European Volume)
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Articles

Giant Cell Tumours of the Tendon Sheath: Lack of Correlation between nm23-H1 Expression and Recurrence

P. LORÉA
H. VAN DE WALLE
L. KINNEN
P. LEDOUX
J-P. MOERMANS
B. VAN DEN HEULE

From the Centre de Chirurgie de la Main, Clinique du Parc Léopold, 38 rue Froissart, 1040 Brussels, Belgium and the Centre of Morphological Pathology, 45A Av Joseph Wybranlaan, 1070 Brussels, Belgium

Correspondence: Dr Patrick Loréa, SOS Main Strasbourg, Clinique des Diaconesses, 4 rue Ste Elisabeth, 67000 Strasbourg, France. Tel.: +33-388354500; E-mail: loreapatrick{at}yahoo.fr

Some authors attribute recurrences of giant cell tumours to biological factors which are only expressed in some tumours. Grover et al. (1998) suggested that the risk for recurrence is associated with the down-regulation of the nm23-H1 gene. We reviewed the charts of the 154 patients operated on for giant cell tumours of the tendon sheath and selected a group of patients with recurrence (ten cases) and a group of patients who did not have a recurrence after a minimum follow-up of 3 years (13 cases). Immunohistochemical detection of nm23-H1 was performed blindly of the clinical outcome on the paraffin-embedded specimens of these patients and no correlation was found between nm23-H1 expression and the risk for recurrence.

Key Words: giant cell tumour tendon sheath • recurrence • nm23 • immunohistochemistry

Journal of Hand Surgery (British and European Volume), Vol. 29, No. 1, 67-70 (2004)
DOI: 10.1016/S0266-7681(03)00222-5
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