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Journal of Hand Surgery (British and European Volume)
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Prostacyclin Analogue (Beraprost) Relief of Cold Intolerance After Digital Replantation and Revascularization

N. ISOGAI
Y. MIYASATO
S. ASAMURA

From the Department of Plastic and Reconstructive Surgery, Kinki University School of Medicine, Osaka-sayama, Japan

Correspondence: Dr Noritaka Isogai,MD, Department of Plastic and Reconstructive Surgery, Kinki University School of Medicine, 377-2 Onohigashi, Osaka-sayama, Osaka Japan. Tel.: +81-723-66-0221; fax: +81-723-67-7517; E-mail: isogai{at}med.kindai.ac.jp

Cold intolerance frequently occurs after successful digital revascularization and replantation. A series of 11 patients with cold intolerance 6 to 24 months after digital revascularization/replantation were treated daily for 2 weeks with beraprost, a stable prostacyclin analogue. That pain was reduced in 9 of 11 cases after treatment and digital thermography showed significantly increased surface temperature after the 2-week course of beraprost. These findings support the use of beraprost to relieve symptoms of cold intolerance under these clinical conditions.

Key Words: cold intolerance • replantation • prostacyclin

Journal of Hand Surgery (British and European Volume), Vol. 29, No. 4, 406-408 (2004)
DOI: 10.1016/J.JHSB.2004.02.010
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