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Dupuytren’s Disease Risk Factors

From the Department of Trauma and Orthopaedics, Derbyshire Royal Infirmary, UK, University of Nottingham Medical School, UK, Division of Respiratory Medicine, Nottingham City Hospital, UK, and Clinical Epidemiology & Respiratory Medicine, Nottingham City Hospital, UK

Correspondence: Mr John M. Geoghegan, 8 Cumbria Grange, Gamston, Nottingham NG2 6LZ, UK. Tel.: +44 1332347141 (work)/+44 1159145495 (home); fax: +441332254950; E-mail: john.geoghegan{at}ntlworld.com

Dupuytren’s is a common problem, but little is known about its a etiology. We have undertaken a large case-control study to assess and quantify the relative contributions of diabetes and epilepsy as risk factors for Dupuytren’s in the community. Cases were patients with a diagnosis of Dupuytren’s disease and, for each, two controls were individually matched by age, sex, and general practice. Our dataset included 821 cases and 1,642 controls. Five hundred and eighty-eight (72%) of the cases were men. The mean age at diagnosis was 62 (range 24–97) years. Diabetes was a significant risk factor for Dupuytren’s disease (OR = 1.75) and there was an increased risk for medicinally treated diabetes (metformin – R = 3.56; sulphonylureas – OR = 1.75) and particularly insulin controlled (OR = 4.39) rather than diet-controlled diabetes. Epilepsy (OR = 1.12) and antiepileptic medications were not associated with Dupuytren’s disease. Ascertainment bias in previous studies may explain the reported association with epilepsy.

Key Words: Dupuytren’s disease • diabetes • epilepsy • case-control study • general practice research database

Journal of Hand Surgery (British and European Volume), Vol. 29, No. 5, 423-426 (2004)
DOI: 10.1016/J.JHSB.2004.06.006


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