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Dupuytren’s Contracture: An Update of Biomolecular Aspects and Therapeutic Perspectives

From the Dipartimento di Discipline Chirurgiche ed Oncologiche, Cattedra di Chirurgia Plastica e Ricostruttiva Università di Palermo, Via del Vespro, Palermo, Italy

Correspondence: Massimiliano Tripoli, Via Andrea Costa no 4–90125 Palermo, Italy. Tel.: +91 6472965. E-mail: matripoli{at}yahoo.it

The so-called fibrogenic cytokines, able to induce the growth of fibroblasts and their differentiation into myofibroblasts and to stimulate their production of extracellular matrix, are involved in the genesis of Dupuytren’s contracture. Although many studies have been made of biomolecular aspects of palmar fibromatosis, practical applications from them are still far from imminent because of the real difficulty of blocking their action in vivo, even in a chronic, progressive lesion such as Dupuytren’s disease. Consequently, surgical excision of the palmar fascia still remains the treatment of choice.

Key Words: Dupuytren’s contracture • flexion • transforming growth factor-beta • alternatives to surgery

Journal of Hand Surgery (British and European Volume), Vol. 30, No. 6, 557-562 (2005)
DOI: 10.1016/J.JHSB.2005.07.002


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