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Journal of Hand Surgery (British and European Volume)
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Articles

Epidermal Growth Factor Receptor (EGF-R) in Dupuytren’s Disease

K. AUGOFF
R. TABOlA
J. KULA
J. GOSK
R. RUTOWSKI

From the Department of Traumatic Surgery and Hand Surgery, Medical University, Wroclaw, Poland

Correspondence: Dr Katarzyna Augoff, Department of Traumatic Surgery and Hand Surgery, Medical University, Traugutta Str. 57/59, 50-417 Wroclaw, POLAND. E-mail: augoffka{at}chir.am.wroc.pl

The aim of this paper was to examine participation of the epidermal growth factor receptor (EGF-R) signal pathway in the pathogenesis of Dupuytren’s disease. The study showed changes in the ratio of membrane EGF-R to its intracellular level during the different clinical stages of Dupuytren’s contracture progression. Our observations of a high ratio of surface to intracellular EGF-R in the palmar aponeurosis of patients with second degree of Dupuytren’s disease (Iselin’s classification), which was significantly higher than this ratio in control palmar fascia (P = 0.022), would suggest that EGF-R has a role in the involutional phase of the disease.

Key Words: epidermal growth factor receptor • EGF-R • Dupuytren’s disease • fibrosis

Journal of Hand Surgery (British and European Volume), Vol. 30, No. 6, 570-573 (2005)
DOI: 10.1016/J.JHSB.2005.06.008
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