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Journal of Hand Surgery (European Volume)
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The Inflammatory Response and Hyaluronan Synthases in the Rabbit Flexor Tendon and Tendon Sheath Following Injury

M. BERGLUND, D. A. HART and M. WIIG

From the Department of Hand Surgery, Uppsala University Hospital, Uppsala, Sweden and the McCaig Centre for Joint Injury and Arthritis Research, University of Calgary, Calgary, Alberta, Canada

Correspondence: Dr Monica Wiig, MD, PhD, Uppsala University Hospital, Uppsala, Sweden. E-mail:monica.wiig{at}akademiska.se

Using a rabbit model of flexor tendon injury, mRNA levels for a subset of relevant molecules involved in inflammatory and fibrotic processes were assessed by reverse transcriptase-polymerase chain reaction 3, 6, 12 and 24 days after injury. Increased levels of COX-2, IL-1β, MMP-13 and TIMP-1 mRNA were detected in both tendon and tendon sheath following injury, with each molecule exhibiting tissue and time-dependent changes. MMP-13 and TIMP-1 mRNA levels were markedly upregulated in both tissues, whereas COX-2 and IL-1β predominantly increased in tendon. Both hyaluronan synthase (HAS) 2 and 3 exhibited increases in mRNA levels in tendon tissue after injury, HAS 2 being more pronounced. These findings support the concept that healing in the flexor tendon and the sheath involve different molecular events and that each tissue may require unique modifications if healing is to be enhanced and adhesions reduced.

Key Words: flexor tendon injury • MRNA levels • hyaluronan synthases • interleukin-1β • cyclooxygenase-2 • inducible nitric oxide synthase

Journal of Hand Surgery (European Volume), Vol. 32, No. 5, 581-587 (2007)
DOI: 10.1016/J.JHSE.2007.05.017
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