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The effect of tissue culture on suture holding strength and degradation in canine tendon

From the Orthopedic Biomechanics Laboratory, Mayo Clinic Rochester, MN, USA

Correspondence: Chunfeng Zhao, MD, 200 First Street, SW Rochester, MN 55905, USA. Tel.: +1 507-538-1717; Fax: +1 507-284-5392. E-mail:zhao.chunfeng{at}mayo.edu.

The purpose of this study was to assess tendon metabolism and suture pull-out strength after simple tendon suture in a tissue culture model. One hundred and twelve flexor digitorum profundus tendons from 28 dogs were cultured for 7, 14, or 21 days with or without a static tensile load. In both groups increased levels of matrix metalloproteinase (MMP) mRNA was noted. Suture pull-out strength did not decrease during tissue culture. While the presence of a static load had no effect on the pull-out strength, it did affect MMP mRNA expression. This tissue culture model could be useful in studying the effect of factors on the tendon-suture interface.

Key Words: tissue culture • matrix metalloproteinases • tendon repair • suture strength

This version was published on October 1, 2009

Journal of Hand Surgery (European Volume), Vol. 34, No. 5, 643-650 (2009)
DOI: 10.1177/1753193409104564


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